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Lions Eye Hospital

Diabetic Retinopathy

What is Diabetic Retinopathy?

Diabetic retinopathy is a complication of diabetes, caused by diabetes damaging the blood vessels in the light sensitive tissue at the back of the eye (retina). It can cause blindness if left undiagnosed and untreated.

The disease can cause fluid leaking into the center of the retina (macular edema) or abnormal blood vessels formation on the surface of the retina (neovascularization) which can bleed and scar resulting in loss of central and possibly peripheral vision.

The four stages of diabetic retinopathy are classified as-

Mild, moderate, severe (nonproliferative), and proliferative.

You might not have symptoms in the early stages of diabetic retinopathy. As the condition progresses, you might develop:

    Spots or dark strings floating in your vision (floaters)

    Blurred vision

    Fluctuating vision

    Dark or empty areas in your vision

   Vision loss



Treatment

 

Eye injections for diabetic retinopathy

 

 

Medicines injected into the eye such as anti-VEGF drugs (eg. Ranibizumab biosimilars, Accentrix,  Avastin , Eylea and Pagenax) and steroids (eg. Triamcinolone and Ozudex) are commonly used to treat diabetic macular edema . Both anti-VEGF and steroid medications have been provento be highly effective in reducing macular edema and improving vision.

The anti-VEGF agents are generally considered as the first line therapy for treating most cases. Repeat injections may be necessary for long-term control of the retinopathy.

The injections are performed in the operation theatre using topical anaesthetic eye drops. They are very well tolerated and complications like infections are rare. Steroid injections may be associated with elevated eye pressure.

 

 

Laser

Laser photocoagulation is a well known treatment for diabetic retinopathy

To perform th eprocedure laser is delivered  to treat the leaky retinal blood vessels or promote shrinkage of abnormal blood vessels (neovascularization)

Laser photocoagulation is performed in the out patient setting with the patient seated in front of the laser unit. The eye is anesthetized with drops and a contact lens may be placed on the eye to focus the laser-aiming beam. Patient may sense bright flashes of lights and occasionally a pinching sensation. Some people may experience discomfort during laser procedure, but is generally well-tolerated .

 

 

Vitrectomy

People with diabetic retinopathy may require vitrectomy surgery in an operating room setting. Vitrectomy is performed when there is bleeding or retinal traction that is causing loss of vision in advanced diabetic retinopathy. In this surgical procedure, small instruments are inserted into the eye under microscopic visualization to remove the vitreous hemorrhage and any scar tissue . Laser photocoagulation may be performed during the surgery, and in some cases, a gas bubble or silicone oil may be injected to hold the retina in position . The prognosis of vision improvement after  vitrectomy surgery depends upon the status of the underlying diabetic retina.

Symptoms

Symptoms to look out for Diabetic Retinopathy

Risk Factors

Who faces a higher risk of developing Diabetic Retinopathy

  • Duration of Diabetes: Longer diabetes duration increases the risk.
  • Poor Blood Sugar Control: High glucose levels damage blood vessels in the retina.
  • Hypertension: High blood pressure exacerbates retinal damage.
  • High Cholesterol: Increases the risk of blood vessel damage.
  • Kidney Disease: Indicates poor blood vessel health, raising the risk.
  • Pregnancy: Can worsen diabetic retinopathy in women with diabetes.
  • Smoking: Damages blood vessels and worsens complications.
  • Obesity: Associated with poor blood sugar and blood pressure control.
  • Age: Older individuals are at higher risk.
  • Ethnicity: Higher prevalence in African, Hispanic, and Indigenous populations.
  • Lack of Regular Eye Exams: Delayed detection worsens progression
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